Posts Tagged ‘efficacy’

Excitement for the debut of Facebook on the Nasdaq

May 18, 2012 - 1:35 pm Comments Off

Facebook knows the title of early febrile Friday on the Nasdaq, the title having erased its gains in early trade, falling to its IPO price before going up .

The title began more than 11% above its IPO price, reaching a high of 45 dollars, according to Reuters data, before losing ground and return to its IPO price, 38 dollars.

The transaction enabled the world's first social network to raise $ 18.4 billion (14.4 billion euros) and to be valued at $ 104 billion, more than Hewlett-Packard and Starbucks combined. 

After a delay in its quotation that fueled the impatience of traders and commentators around the world, the title began in Facebook stock at 1530 GMT at 42.05 dollars.

The group's headquarters in Silicon Valley and the applause of his employees, the founder and CEO of Facebook Mark Zuckerberg, 28, rang the bell to mark the debut of Exchange community site for 900 million users.

Outside the offices of the company thronged reporters and photographers. Above their heads, even a helicopter had been sent by U.S. television on the occasion of the IPO, the largest history of American technology stocks.

"A jump of 15% to 20% is about as possible," thought Tim Loughran, a finance professor at the University of Notre Dame, Indiana, before the start of trading .

Some investors believe the stock could gain 30% or more, on Friday despite persistent questions about the actual ability of Facebook to generate sustainable profits.

After just one hour of trading, Pivotal Research Group already recommended to sell the security. 

"The market is currently valuing Facebook as an asset less risky than Google, which we believe is absolutely not the case," said Brian Wieser, one of the firm's analysts in a research note .

The average of analysts' estimates compiled by Morningstar predicts a closing price Friday of $ 50.

At 16:30 GMT, gained 9.53% to 41.62 dollars.

Agreement on the budget 2013 in the Netherlands

April 26, 2012 - 9:55 pm Comments Off

The 2013 draft budget, which aims to reduce the fiscal deficit to 3% of GDP, is assured of a majority in the Dutch Parliament after the agreement between the two parties in the outgoing coalition and the three opposition parties, said Thursday news agency ANP.

"My party has given me the green light to the plan that we discussed," said Sybrand van Thursday Haersma Buma, leader of the Christian Democrats in the lower house of Parliament .

Stef Blok, leader of the parliamentary Liberal, has also announced that its base had agreed, as the three opposition parties, Democrats 66, Christian Union VertGauche and, depending on the television channel NOS. 

The ruling coalition broke out during the weekend due to the inability to agree on conservation measures designed to meet the reduction targets budget deficit ; silence as part of the European Union.

The government has sought to obtain a circumstantial majority in Parliament to pass his economic plan before Monday, when it is supposed to present in Brussels.

Discussions were held with the two parties forming the government (the Liberals and Christian Democrats), with three opposition parties (Democrats 66, and the Union VertGauche Christian) and with perhaps one or two other courses. 

With the support of all three opposition parties, the government will have a majority of 77 seats out of 150 in the lower house of Parliament.

European stock markets continue to rebound

April 25, 2012 - 11:35 am Comments Off

European shares closed Wednesday up sharply, the results found solid companies' published eclipsing concerns about the debt crisis in the eurozone.

The CAC 40 index, which had ended with a gain of 2.29% Tuesday, ended up 2.02% to 3233.46 points.

The Frankfurt Stock Exchange rose 1.73%, that of Madrid by 1.7% while the London market (0.16%) suffered from the recession back to the UK economy .

In this context, cyclicals and financials were particularly popular, pan-European Stoxx index of bank earning 1.86% in the provisional closure and the auto 3 , 05%, fastest growing sector in Europe.

Human Genome rejects the offer of $ 2.6 billion from GSK

April 19, 2012 - 9:55 pm Comments Off

Human Genome Sciences announced Thursday it had rejected an unsolicited offer of his longtime partner GlaxoSmithKline that values ​​around 2.6 billion (2 billion).

GSK's offer, to 13 dollars per share, represents a premium of 81% over the closing price of 7.17 dollars for action Human Genome Wednesday night, but the U.S. group believes it does not reflect its intrinsic value.

In pre-market Human Genome soared over 100% to trade at just over $ 15, a sign that the market is betting on a bidding war in this new battle that promises to within a pharmaceutical industry recently marked by a wave of consolidation. 

Human Genome, American laboratory that specializes in gene isolation and identification of their function in the development of new drugs, said banks have mandated Goldman Sachs and Cre Swiss said the counselor.

First British pharmaceutical company, GSK said he was disappointed in a statement of rejection of his offer without discussion. The group confirmed its offer, stating that the proposed price of $ 13 would be paid in cash.

He also said to expect the transaction provides for the realization by 2015 at least $ 200 million of cost synergies, and that it will be accretive to from 2013.

If GSK has been a tendency in the past not to buy out partners with whom he works, the rumor of an offer to GSK on its U.S. partner ran long, the two companies already collaborate ; over several treatments, including Benlysta, the first new drug against lupus in more than half a century.

Navid Malik, analyst at Cenkos Securities, indicates that GSK extremely knowledgeable Human Genome and must point to a potential value in excess of one Benlysta. 

Both groups are also working on a project called darapladib treatment of heart, now in the third and final phase of experimental tests.

If product development is going to an end, analysts see it as a "blockbuster" possible multi-billion dollar per year, although the molecule is also accompanied by a high level of risks.

A banker in the health sector considers the offer of generous and GSK believes that certain shareholders of Human Genome could accept it.

Others, however, prefer to wait an increase of the price. They know the appetite of big pharmaceutical companies for biotech in their search for new growth after the expiration of patents on several of their blockbuster drugs.

As recently as Wednesday, the American Illumina rejected a hostile bid of 6.8 billion dollars (5.2 billion euros) of the Swiss laboratory Roche Holding.

Total requisitions favor in the case of Erika

April 6, 2012 - 5:35 pm Comments Off

The Prosecutor General of the Supreme Court has definitively cancel the condemnation of Total over 12 years near the wreck of the tanker Erika off the Brittany coast in 1999, which caused ; a major ecological disaster.

This 24-year-old ship broke in two on 12 December 1999 in a storm and sank, spilling 20,000 tonnes of fuel on 400 km of the Breton coast, killing dozens thousands of birds and ravaging the seabed.

The prosecution based its opinion on the fact that the disaster has not occurred in French waters but "exclusive economic zone" (EEZ), and that the ship flew the Maltese flag, which would remove any possibility of prosecution in criminal justice. 

The Court of Cassation, the highest French court, which will meet May 24 and will make the final decision after a deliberate, however, is not bound to follow the opinion of floor, reading was revealed by Liberation and Ouest-France.

The public prosecutor asked the permanent cancellation without retrial, the conviction for "marine pollution" of the first French company announced after two die decisions at first instance and on appeal in 2008 in 2010.

In addition to the Total group, sentenced to a fine of 375,000 euros, Rina, the Italian maritime regulatory body which gave its airworthiness certificate to the ship (175.000 euro fine), Giuseppe Savarese, a former Italian owner of the ship, and Antonio Pollara, Italian former manager of the Erika (75,000 euro fine each) were convicted in appeal.

The lower courts have so far retained the right of other interpretations. The plaintiffs believe that the French territory was hit by the effects of the offense is sufficient to render the French competent judges.

THE ENVIRONMENTAL DAMAGE IN DANGER

The floor of the Court of Cassation also recommends abandoning the notion of "environmental damage" introduced in 2008 by the trial judgment that can demand compensation for environmental damage , as well as for moral harm, economic or property.

After a review of the complex thicket of international conventions governing shipping, the prosecutor's office believes it is impossible to legalize this notion. 

Corinne Lepage, one of the lawyers of the plaintiffs and former environment minister, said that it was here that a notice and hoped that the Court would not follow him.

"It would be a double disaster legal, not for the common (…) but in terms of law in general because it means that charterers could continue to take as Total boat was rotten like the Erika for reasons of pure greed and polluting the coast without nothing happens, "she said on RTL. 

NO EFFECT ON PAYMENTS

The folder is marked from the beginning by a very complex debate, shipping is governed by a series of international conventions and national laws very bushy, with idé e general far as the charterer of a tanker is in principle not liable criminally or civilly.

The Court of Appeal had also, on this point, not fully completed the first judgment, concluding that Total was guilty but not criminally responsible civilly.

This point has not had an immediate effect because Total has already paid in 2009 without possible cancellation of 170 192 500 000 compensation ordered in the first instance in 2008, 153 for the state. Rina has paid the surplus, and an "extension" decided on appeal where the total bill rose to 200.6 million euros.

Total said it would ask for a refund, whatever the final decision to the Supreme Court, where lawyers of some 80 civil parties, municipalities, regions, departments and advocacy groups the environment will plead.

French society has always said he was the victim of a "hidden defect" of the boat, never a thesis accepted by the court. 

Given another 200 million euros paid by the company in 1999, including the cleaning of beaches and pumping oil from the wreck, the total bill to stu ve for it to nearly 400 million euros, an amount limited compared with the annual profit of nearly $ 12 billion company.

COR-A-kilns ArcelorMittal Schifflange closed indefinitely

March 20, 2012 - 8:35 pm Comments Off

ArcelorMittal said Tuesday it was extending indefinitely the closure of the voltaic arc furnace from its site of Schifflange Luxembourg, which has 282 employees.

The world's number one steel explained his decision by the depressed construction market in Western Europe, which are for products Schifflange, and said he could see no sign of significant improvement since the crisis that hit the area at the end of 2008.

Schifflange site specializes in the production of long carbon steel.

French President Nicolas Sarkozy announced earlier this month that ArcelorMittal would restart a blast furnace of its French site Florange (Moselle). But the group had then stated that it would be restarted in case of economic recovery.

The Tokyo Stock Exchange finished up 2%, optimism on Greece

March 8, 2012 - 4:35 am Comments Off

The Tokyo Stock Exchange ended on a sharp rise from 2.01% Thursday, buoyed by optimism about employment in the United States and the level of participation of private creditors to Greek debt exchange.

After three sessions of declines, the Nikkei index is back above the 9,700 point mark, gaining 192.90 points to 9,768.96 and the Topix broader, took 13.45 Points (1.63%) to 836.16.

The trend was also supported by a Wall Street Journal suggesting that the Fed is considering a new approach to bond buybacks.

Values, the technology has benefited from a presentation by Apple's new version of its iPad tablet.

Toshiba took 1.77% and 4.1% Electronics Renesas.

The unemployment rate in France is approaching 10%

March 1, 2012 - 5:25 am Comments Off

The unemployment rate in France in late 2011 now stands at 9.8%, up 0.1 points over one year. A total of 3.4 million people are seeking employment. Agency employment center in Nice

The unemployment rate in France rose by 0.1 points in the fourth quarter 2011 compared to the previous quarter to 9.4% of the workforce (9.8% overseas departments included), announced the INSEE Thursday. This rate, calculated according to the standards of the International Labour Office (ILO), was also up 0.1 points versus the fourth quarter of 2010, INSEE said.

In France, 2,678,000 people were unemployed on average in the fourth quarter. But in total, 3.4 million people were unemployed and wanted to still work, or not available for this within two weeks and looking for work or not. This is the third consecutive increase, after the unemployment rate in the third quarter (9.3%) and second quarter 2011 (9.1%).

Labour Minister Xavier Bertrand noted but noted that "France has fared better than its main partners to the global crisis" between the second quarter 2007 and third quarter of 2011, citing OECD data. Unemployment among 15-24 year olds, great concern of the government, rose by 0.8 point compared to the previous quarter and by 0.2 percent yoy. The youth unemployment rate rises from 21.6% to 22.4%, or about 626,000 people.

Involuntary part-time increases

The unemployment rate for seniors is improving slightly on the contrary, down 0.1 points from the previous quarter. It remains up (0.2 pt) to the last quarter of 2010. Some 485,000 people aged over 50 were looking for a job in the last quarter of 2011. The employment rate of older, more and more likely to stay in business with the successive reforms of pensions, continued to grow (a point on the previous quarter, 1.6 points over one year). The increase was pronounced for those aged 55-64 (1.4 pt in the quarter, 2.8 points over one year).

The employment rate in permanent contract (CDI) is stable in the fourth quarter of 2011, to 48.7% of the population aged 15-64. Rate for those employed in CDD / Acting rose slightly and stood at 6.8%. Partial unemployment, the government and social partners come to reform to facilitate its implementation, down 0.3 percentage points and stood at 0.2% of employed persons. Involuntary part-time increased slightly to 5% of people with jobs. Finally, the unemployment rate is declining in women (-0.1 pt the quarter, -0.3 pt yoy) as he progresses on the contrary men (0.4 pt the quarter , 0.6 pt yoy).

Swatch will create 1000 jobs, target of 8 billion francs CA

February 26, 2012 - 2:35 pm Comments Off

The Swiss watchmaker Swatch plans to create 1,000 jobs worldwide and generate a turnover of 8 billion Swiss francs (6.64 billion euros) this year, said Sunday its CEO Nick Hayek told Der Sonntag.

Nick Hayek regularly manifests its opposition to the strong Swiss franc, which penalizes exports Helvetic.

"We want as close as possible to the threshold of 8 billion francs," he told the Sunday newspaper.

"This will be possible if there is no economic or political disaster, and that exchange rates remain stable or improve."

In early January, Swatch Group announced a turnover of more than seven billion francs, after a double-digit growth in sales of watches and jewelry division.

TNT Express takes off on the stock exchange, exceeds the bid for UPS

February 20, 2012 - 6:00 am Comments Off

The action of TNT Express flew more than 50% Monday on the exchanges of Amsterdam, beyond the purchase price offered by the American UPS, indicating that investors expect a proposal for enhanced .

UPS said Friday it had offered € 9 per share to buy the Dutch group messaging, valuing it around 4.9 billion euros. TNT Express has rejected the offer, but discussions are continuing between the two groups.

The action was traded to TNT 9:50 GMT around 9.80 euros, up 54% from its closing price on Friday night (6.343 euros).